Intranasal delivery of PEA-producing Lactobacillus paracasei F19 alleviates SARS CoV-2 spike protein-induced lung injury in mice

Autore: Alessandro Del Re1* , Silvia Basili Franzin1, Jie Lu2,3, Irene Palenca1, Aurora Zilli1, Federico Pepi4, Anna Troiani4, Luisa Seguella1, Marcella Pesce5, Giovanni Esposito3,6, Giovanni Sarnelli3,6 and Giuseppe Esposito

1 Department of Physiology and Pharmacology “V. Erspamer”, La Sapienza University of Rome, 2 Department of Anatomy and Cell Biology, China Medical University, 3 Nextbiomics S.R.L., Naples, 4 Dipartimento di Chimica e Tecnologie del Farmaco, “Sapienza” University of Rome, 5 Department of Clinical Medicine and Surgery, Section of Gastroenterology, University Federico II, Naples, 6 Department of Molecular Medicine and Medical Biotechnologies, Centro Ingegneria Genetica- Biotecnologie Avanzate, Naples,

Intranasal delivery of PEA-producing Lactobacillus paracasei F19 alleviates SARSCoV-2 spike protein-induced lung injury in mice